Mary-Louise Parker (born August 2, 1964) is an American actress. Best known for her lead role on Showtime's television series Weeds portraying Nancy Botwin, she received the Golden Globe Award for Best Actress in 2006. Parker has appeared in films and series such as RED, RED 2, Fried Green Tomatoes, Boys on the Side, The West Wing, and Angels in America, for which she received a Golden Globe and an Emmy Award for Best Supporting Actress.